https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Nephrotoxicity in rats exposed to paracetamol: the protective role of moralbosteroid, a steroidal glycoside https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32515 M. alba stem bark. Nephrotoxicity was induced with administration of paracetamol. Nephroprotection was studied using two doses of the extract. The experimental animals were divided into four groups (n = 6). Two groups served as positive and negative controls, respectively, and two received the test substances. All of the contents were orally administered. Significant reductions in nephrotoxicity and oxidative damages were observed in the treatment groups. There was a marked decrease in blood levels of urea, creatinine, and lipid peroxidation. Furthermore, it was found that glutathione levels in the blood increased dramatically after treatment. Histological findings confirmed the potent renoprotective potential of moralbosteroid. This was evidenced by the minimized intensity of nephritic cellular destruction. In animal studies, moralbosteroid exhibited dose-dependent activity, which is thought to be mediated through its antioxidant potential.]]> Wed 13 Jun 2018 11:02:23 AEST ]]> Longer-term Mortality and Kidney Outcomes of Participants in the Combination Antibiotics for Methicillin-Resistant Staphylococcus aureus (CAMERA2) Trial: A Post Hoc Analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54430 Tue 27 Feb 2024 13:58:29 AEDT ]]> Flucloxacillin worsens while imipenem–cilastatin protects against vancomycin-induced kidney injury in a translational rat model https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54577 Sat 02 Mar 2024 10:02:38 AEDT ]]>